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莫莫替尼是Janus激酶JAK1和JAK2的抑制剂,是ATP竞争剂,IC50分别为11和18 nM。该抑制剂对其他激酶(包括JAK3)的活性显着降低。截至2011年,莫莫替尼正被开发为治疗骨髓纤维化的药物,目前正在进行I / II期临床试验。莫莫替尼的其他潜在治疗适应症包括其他骨髓增生性肿瘤,癌症和炎症性疾病。截至2016年,正在研究momelotinib的原发性骨髓纤维化或真性红细胞增多症后或原发性血小板增多症后骨髓纤维化,以及治疗复发性或难治性转移性胰腺导管腺癌。
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