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Fedratinib(也称为fedratinib盐酸盐)是一种口服的Janus激酶2半选择性抑制剂,用于治疗骨髓增生性疾病(包括骨髓纤维化)患者。Fedratinib充当蛋白的竞争性抑制剂激酶JAK-2与IC 50 = 6纳米;相关激酶FLT3和RET分别也敏感,其IC 50 = 25nM的IC 50和= 17纳米。观察到针对包括JAK3的其他酪氨酸激酶的活性显着降低。在处理过的细胞中,抑制剂阻断下游的细胞信号传导,导致增殖的抑制和凋亡的诱导。我于2019年8月16日获得FDA批准。骨髓纤维化是一种与贫血,脾肿大和全身症状相关的髓样恶性肿瘤。骨髓纤维化患者经常携带对TG101348敏感的JAK-STAT激活突变。2011年发表了针对高危或中危原发性或后发性真性红细胞增多症/原发性血小板增多症骨髓纤维化患者的Fedratinib的安全性和有效性的I期试验结果。
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Sequence Logo is an online tool for creating sequence logos. Paste your multiple sequence alignment and the sequence logo is generated automatically. Use Sequence Logo to easily create vector sequence logo graphs.

Please refer to the Sequence Logo manual for the sequence logo parameters and configuration. Sequence Logo supports multiple color schemes and download formats.

Sequence Logo is sequence logo generator. Sequence logos visualize protein and nucleic acid motifs and patterns identified through multiple sequence alignment.

Te Reo Maps is an online interactive Maori mapping service. All labels in Te Reo Maps are in Maori, making it the first interactive Maori map. Te Reo Maps is the world map, with all countries and territories translated into Maori.

Please refer to the list of countries in Maori for the Maori translations of country names. The list includes all UN members and sovereign territories.